Itanium architecture supports the popular operating system Windows Server. You will need to install Windows Server IA64 Edition. It is a 64bit Operating System and supports the popular MS SQL Server.
MS Biztalk, MS Office and other Microsoft Applications may have compatability issues with Itanium based servers running on Windows IA64 Edition.
Depending on how your application was written, you will need to either turn the hyperthread as on or off. Do a proper benchmark tests with both scenarios.
As a rule of the thumb, leave it to the OS to manage the hyperthreads in your application. Only is very rare occassions that you will have to manage the hyperthreads yourself.
Do provide me with some feedback on how your applications performed on X64 and IA64 platforms.
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